Spurs are set to play rivals Chelsea on Wednesday for the first of the two legged semi-final, with Conte facing his former side for the first time since his departure in 2018.
The Italian won a Premier League title along with an FA Cup during his two seasons in west London and is now eyeing his first trophy in charge of Tottenham.
But Spurs could be dealt yet another blow to their jam-packed fixture schedule with several potential Covid cases among the squad.
Conte’s side suffered an outbreak in December in which nine first-team players along with several other members of staff had to self-isolate due to testing positive for the virus.
The former Inter boss confirmed that there may been another outbreak which could see several stars miss out on the first leg, having already had matches against Brighton, Rennes and Leicester called off.
Conte said: “We are checking a couple of situations about Covid.”
He went on to clarify: “Yeah, players. We didn’t do this (name them) in the past and we will continue to do this in the same way.
“We are not 100 per cent sure they will miss the game.”
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The manager added that the players in question are still awaiting the results of their PCR tests.
Conte also went on to reflect on his time with the Blues and admitted he was looking forward to his return to the stadium.
He said: “For me for sure it will be great to come back to Stamford Bridge as [it is the] first time after I left Chelsea as manager to come back Stamford Bridge.
“What I can say is that I spent two amazing seasons, created lot of friendship in the club.”
Tottenham will be hoping they have their full strength squad available as they eye their first bit of silverware since 2008, where they won the same competition.